Adeline Sylvia Eugenia Ama Yeboakua Akufo-Addo was the wife of Edward Akufo-Addo the mother of Ghanaian President Nana Akufo-Addo. She was also the First Lady in the second republic of Ghana.

She was born to Sir Ofori Atta I, Omanhene of Akyem Abuakwa, and Agnes Akosua Dodua of Abomosu. She is the sister of Susan Ofori-Atta, the first female doctor from the Gold Coast. She is also the sister of William Ofori-Atta, the Gold Coast politician and lawyer, former foreign minister, and one of the founding leaders of the United Gold Coast Convention (UGCC) and the Big Six.

Adeline Akufo-Addo was also the sister of Kofi Asante Ofori-Atta, a Minister for Local Government in the Convention People's Party (CPP) government of Kwame Nkrumah and later Speaker of the Parliament of Ghana.

She died on 21 March 2004 at the Korle-Bu Teaching Hospital in Accra, aged 86.

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