Barbara Asher Ayisi is a Ghanaian politician and a Member of the Parliament of Cape Coast North Constituency in the Central Region of Ghana.

She was born on 12th February 1976 in Efutu, Central Region of Ghana. She attended the Our Lady of Apostles (OLA) College of Education and the University of Education, Winneba. She also obtained a Master's Degree in English literature from the University of Cape Coast.

Barbara Asher Ayisi was a form mistress between 2003 and 2006 with the Ghana Education Service and former house mistress of the Wesley Girls’ Senior High School from 2010 to 2016. She was also the Deputy Minister for Education in charge of basic schools.

She has a foundation called the Barbra Asher Foundation which focuses on reducing unemployment among the youth in her constituency.

The Barbra Asher Foundation in collaboration with the Cape Coast Technical University's Entrepreneurship Development and Innovation has trained over 200 youth in the Cape Coast constituency in entrepreneurial skills.

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