Mercy Yvonne Debrah-Karikari is a Ghanaian diplomat and the first female to be the secretary to the cabinet of the government of Ghana. She was appointed to occupy this position by the current President Nana Akufo-Addo. Her appointment took effect on the 14th of February 2017.

Mercy attended Wesley Girls Senior High School and Tema Secondary School in Cape Coast and Tema respectively. She obtained a degree in Arts from the University of Cape Coast from 1979 to 1986. She then went ahead to earn a master's degree in International Affairs from the University of Ghana from 1988 to 1989.

Mrs. Debrah-Karikari served as the Head of Chancery at the Ghana Embassy in Luanda, Angola from 1994 to 1995. She was then posted to the United Nations, Ghana Permanent Mission in New York where she served as Consular, and Ghana's delegate on the Second Committee of the United Nations.

Having returned from her mission in 1988, Mercy occupied the position, of acting Director of the International Organizations and Conferences Bureau at the Ministry of Foreign Affairs.

From 2000 to 2002, Mercy served as Minister-Consular at the Ghana Embassy in Bonn and continued at the Ghana Embassy in Berlin from 2002 to 2004. She then proceeded to serve as the Director of the Office of the Minister of Foreign Affairs from 2004 to 2007.

In 2007 she was posted to work at the Ghana Permanent Mission to the United Nations Office in Geneva as Minister and Deputy Permanent Representative till 2011. In July 2014 she was appointed High Commissioner by former President John Mahama.

Before her appointment as Secretary to Cabinet in 2017, she served as Ghana's High Commissioner to Australia in the John Mahama administration.

Mercy is married to Dr. Paul Debrah-Karikari, a consultant neuroradiologist.

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