Sophia Karen Edem Ackuaku is a Ghanaian politician and a Member of the Seventh Parliament of the Fourth Republic of Ghana representing the Domeabra-Obom Constituency. She is a member of the National Democratic Congress.

Sophia was born on 7 October 1972 and hails from Anyako in the Volta Region of Ghana.

She has certificates in public relations, advertisement, and marketing from the Ghana Institute of Journalism and obtained a diploma in social work from the School of Social Work in Osu-Accra, proficiency in the Dutch Language from Zadkine College in Rotterdam, Holland. Ackuaku also has a certificate in leadership, human rights, and HIV/AIDS from the Ark Foundation in Ghana.

Prior to her career in politics, she worked as the Deputy Executive Director in charge of operations at the Ghana National Service Scheme, from 2013 to 2016 and served on the Food, Agriculture and Cocoa Affairs Committee and the Poverty Reduction Strategy Committee of parliament.

She was the Deputy Manager at Golden Souvenir Lotto in the Northern Region of Ghana from 1995 to 2000 and from 2004 to 2013, she was a Managing Director at Eligreen/Amsos Ghana Limited. She has also worked with the FBWE focal person for the Federation of Business Women Entrepreneurs from 2001 to 2010.

Sophia won the parliamentary seat for the Domeabra-Obom Constituency in the 2016 Ghanaian general elections, contesting against Darison Barba Mohammed of the New Patriotic Party, Ekow Jones Mensah of the Conventions People's Party, Gideon Dudu of the Progressive People's Party and Pius Kwame Fiakuna an independent candidate.

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