At the 2010 FIFA World Cup in South Africa, the most famous moment was when Gyan missed a penalty against the same team. This broke Ghana and Africa's first ever hopes of making it to the semi-finals.
After Andre missed a penalty kick in the 21st minute and Ghana left the tournament with two losses and a win in Group H, some people think that the country is cursed.
Gyan, who has scored the most goals for Africa at the World Cup, thinks that things like this are common in football.
"It doesn't seem like a curse to me. All of these things happen in football, and if you play the game, you have to deal with them for the rest of your life."
"I have been there before and I know what Andre (Ayew) is going through right now. He might act like he is strong, but he will feel the pain inside."
"The most important thing is that Uruguay also ended up hurting. So everything is fine." Asamoah Gyan told SuperSport.